Wednesday, March 12, 2025

The Wellness Home: A Gateway to a Healthier, Longer Life

 The Wellness Home: A Gateway to a Healthier, Longer Life

In today’s fast-paced world, where stress and environmental toxins are at an all-time high, creating a wellness-focused home has never been more essential. The concept of a wellness home is rooted in designing a living space that nurtures both physical and mental well-being. By incorporating holistic elements, advanced technology, and natural materials, a wellness home enhances daily life, promotes longevity, and provides numerous health benefits.

What Is a Wellness Home?


A wellness home is a thoughtfully designed space that prioritizes health, comfort, and sustainability. Unlike a traditional home, which focuses primarily on aesthetics and functionality, a wellness home integrates air purification, water filtration, circadian lighting, non-toxic materials, and nature-inspired elements. It is a holistic environment where every detail is curated to optimize overall well-being.

How a Wellness Home Enhances Daily Life

1. Improved Air Quality

Poor indoor air quality can lead to respiratory issues, allergies, and chronic illnesses. A wellness home features advanced air purification systems, low-VOC (volatile organic compound) paints, and indoor plants that act as natural air filters. This ensures cleaner, healthier air, reducing the risk of respiratory diseases and promoting overall well-being.

2. Optimized Water Quality

Water contamination is a growing concern, and many tap water sources contain harmful chemicals such as chlorine, fluoride, and heavy metals. A wellness home incorporates high-quality water filtration systems to ensure access to clean, mineral-rich water that supports hydration, detoxification, and overall health.

3. Circadian Rhythm Support



Lighting plays a crucial role in regulating sleep-wake cycles. Traditional artificial lighting can disrupt melatonin production, leading to sleep disorders and fatigue. A wellness home includes circadian lighting systems that adjust to natural light patterns, enhancing sleep quality and boosting energy levels throughout the day.

4. Mindful Spaces for Relaxation


Mental health is as important as physical health. A wellness home includes designated areas for relaxation, meditation, and mindfulness practices. These spaces often feature natural elements like indoor gardens, water features, and calming colors that reduce stress and promote emotional balance.

5. Sustainable and Non-Toxic Materials



Many conventional building materials and furniture contain harmful chemicals that can affect health over time. Wellness homes use eco-friendly, non-toxic materials such as bamboo flooring, organic cotton textiles, and chemical-free paints, reducing exposure to harmful substances.

How a Wellness Home Contributes to Longevity

1. Reduced Exposure to Toxins

Minimizing exposure to environmental toxins plays a key role in preventing chronic diseases and premature aging. Wellness homes reduce toxic exposure through clean air, purified water, and sustainable materials, supporting long-term health.

2. Enhanced Sleep Quality


Quality sleep is directly linked to longevity. Circadian lighting, soundproofing, and ergonomic mattress choices in a wellness home promote deeper, restorative sleep, reducing stress levels and improving overall health. Do you find it hard to get a good night's sleep? You're not alone.

We live in a world that's always on, and switching off can be challenging. But guess what? There’s a natural, soothing solution that may just make your nights more restful - aromatherapy!

You may already be familiar with the concept of aromatherapy - using scents to promote wellness. It's an age-old practice, and it's been making quite a comeback recently. But did you know that specific aromatherapy scents can help you sleep better?

Lavender is a well-known sleep aid. It's been widely studied and associated with improved sleep quality. Bergamot and chamomile are other common oils used in aromatherapy for sleep. They are believed to induce sleep by reducing stress and promoting relaxation.

But there are also some less known but equally effective oils like Valerian oil, Clary Sage, and Sweet Marjoram. They have been praised for their calming effects and ability to promote natural sleep. And let's not forget about sandalwood and jasmine. If you prefer something a bit more exotic, these essential oils might be your ticket to dreamland.

You might be wondering how to use these oils. It's simple, really. You can add a few drops to your diffuser before bedtime, or mix them with a carrier oil and apply directly to your skin. Just remember, everyone is different, so what works for one person might not work for another. It's all about finding the right scent that works for you.

A friend of mine, who has been battling insomnia for years, swears by her nightly routine of a warm bath infused with a few drops of lavender and chamomile oils. She tells me it's like a 'snooze button' for her brain.

So why not give it a try? You might just find the perfect scent to whisk you off into dreamland. And remember, a good night's sleep is not a luxury; it's a necessity for maintaining our overall health.


3. Encouragement of an Active Lifestyle

Wellness homes are designed to encourage movement and physical activity. Whether through built-in home gyms, yoga studios, or standing workstations, these features help promote an active lifestyle, which is crucial for longevity.

4. Stress Reduction


Chronic stress is a leading factor in many age-related diseases. By incorporating biophilic design (which integrates natural elements into the home), sound therapy, and relaxation areas, wellness homes help lower stress hormones, fostering mental clarity and long-term health.

5. Support for Healthy Eating Habits

A wellness home may include a kitchen designed for healthy meal preparation, featuring non-toxic cookware, organic food storage solutions, and even indoor gardens for fresh herbs and vegetables. These elements encourage healthier eating habits, which contribute to a longer lifespan.

Additional Benefits of a Wellness Home

1. Increased Productivity and Focus

A wellness home is designed to optimize productivity by reducing distractions, incorporating natural lighting, and improving air quality. Whether working from home or engaging in creative activities, these factors contribute to enhanced focus and cognitive function.

2. Strengthened Immune System

By reducing exposure to toxins, improving air and water quality, and fostering stress reduction, wellness homes support a stronger immune system, helping the body fight off illnesses more effectively.

3. Enhanced Social and Emotional Well-Being

A wellness home fosters positive social interactions by incorporating open, inviting spaces for family and friends. Strong social connections are linked to increased happiness and longevity.

4. Multi-Generational Living


MULTI-GENERATIONAL ADU (Accessory Dwelling Unit)

Final Thoughts

Investing in a wellness home is a proactive approach to living a healthier, longer, and more fulfilling life. By integrating thoughtful design, advanced wellness technologies, and sustainable materials, a wellness home becomes more than just a place to live—it becomes a sanctuary that nurtures body, mind, and soul. Whether you are building a new home or making small changes to your existing space, adopting wellness-focused elements can have profound effects on your daily life and long-term health.

Tuesday, March 11, 2025

Cystic Fibrosis-Related Arthritis: Who, What, Why, and How?

Do you or a loved one have cystic fibrosis?  CF is known for its severe pulmonary issues.  Recent new chloride channel upregulation (Trikafta) has radically altered lives and increased life spans to near normal.


As patients mature they will exhibit diseases such as arthritis. Many will also grapple with CF-related diabetes.

How little we know about CFA and its treatment. There’s a substantial lack of research on CFA because of the complexity of this complication, although it significantly affects quality of life. Here’s the who, what, why, and how according to the current research and the holes in information that need to be filled to better manage CFA.

Who has cystic fibrosis-related arthritis?

According to the Cystic Fibrosis Patient Registry from 2018, six percent of the population reported cystic fibrosis-related arthritis as a complication of CF.1 In another report, CFA had an estimated prevalence rate of 2% to 8.5%, but is thought to increase as people with CF live longer.2

Although both children and adults can experience CFA, the average age of onset is around 13.6 years and 17 years, respectively.3,4 What I found most interesting was the occurrence of CFA didn't differ based on pulmonary function, sputum cultures, or gastrointestinal symptoms.2

What is cystic fibrosis-related arthritis?

Unfortunately, there is no formal definition of CFA other than recurrent episodes of joint pain, swelling, tenderness, stiffness, and limited mobility sometimes in conjunction with fever or rashes.2 The large joints such as knees, wrists, elbows, and shoulders are the most common joints affected. Often, the pain is not symmetric across joints and can affect different sets of joints with each episode.2

Generally, episodes of CFA can last for up to a week or occur chronically without symptoms resolving completely.2 More often a “remitting and relapsing” course occurs where symptoms get worse and then get better until the next attack. Even with persistent disease, patients often don’t meet the criteria to be diagnosed with rheumatoid arthritis. Results are often normal during X-rays of the affected joints. The vague collection of symptoms makes it especially hard to diagnose and treat CFA, especially because each patient’s experience is different.

Why does CF-related arthritis happen?

The mechanism of CFA is not fully understood or known. A couple theories exist that could explain why CFA happens in people living with CF. The hyperactive immune response from chronic lung infections and inflammation is thought to be the reactive source of joint pain.4 Moreover, because there’s persistent infection and, therefore, inflammation, the immune system works overtime causing an inflammatory reaction within the joints. Makes sense to me! However, no specific antigen in the immune response has been identified.

Another theory is that some people with CF are genetically predisposed to develop CFA.4 Just as salty skinclubbing, or occasional pancreatic sufficiency are physical traits of CF, or genetic phenotypes, some researchers believe inflammatory arthritis is another phenotype that can be expressed in the disease. However, there’s been no further research studying CFTR genotypes and CFA.

The last theory explaining CFA is connected to gastroenterology complications of CF such as malabsorption and other GI issues. Many other arthritic syndromes are connected to GI diseases such as inflammatory bowel disease, entheogenic reactive arthritis (arthritis caused by an infection in the intestines), and arthritis of intestinal bypass surgery.4 All varieties have similar characteristics as CFA and could give a possible explanation to a link in CF.

Bottom line: there needs to be more research.


Cystic Fibrosis-Related Arthritis: Who, What, Why, and How?

Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects

 

Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects

A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide—also known as Ozempic—in suppressing appetite and reducing body weight. Notably, testing in animals also showed that it worked without some of the drug’s side effects, such as nausea, constipation, and significant loss of muscle mass.

The newly discovered molecule, BRP, acts through a separate but similar metabolic pathway and activates different neurons in the brain — seemingly offering a more targeted approach to body weight reduction.

“The receptors targeted by semaglutide are found in the brain but also in the gut, pancreas, and other tissues,” said assistant professor of pathology Katrin Svensson, PhD. “That’s why Ozempic has widespread effects including slowing the movement of food through the digestive tract and lowering blood sugar levels. In contrast, BRP appears to act specifically in the hypothalamus, which controls appetite and metabolism.”

The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. Prohormones are biologically inert molecules that become active when they are cleaved by other proteins into smaller pieces called peptides; some of these peptides then function as hormones to regulate complex biological outcomes, including energy metabolism, in the brain and other organs.

Katrin Svensson
Katrin Svensson

Each prohormone can be divided in a variety of ways to create a plethora of functional peptide progeny. But with traditional methods of protein isolation, it’s difficult to pick peptide hormones (which are relatively rare) out of the biological soup of the much more numerous natural byproducts of protein degradation and processing.

The researchers focused on the prohormone convertase 1/3, which separates prohormones at specific amino acid sequences and is known to be involved in human obesity. One of the peptide products is glucagon-like peptide 1, or GLP-1, which regulates appetite and blood sugar levels; semaglutide works by mimicking the effect of GLP-1 in the body. The team turned to artificial intelligence to help them identify other peptides involved in energy metabolism.

Peptide Predictor

Instead of manually isolating proteins and peptides from tissues and using techniques like mass spectrometry to identify hundreds of thousands of peptides, the researchers designed a computer algorithm they named Peptide Predictor to identify typical prohormone convertase cleavage sites in all 20,000 human protein-coding genes. They then focused on genes that encode proteins that are secreted outside the cell — a key characteristic of hormones — and that have four or more possible cleavage sites. Doing so narrowed down the search to 373 prohormones, a manageable number to screen for their biological effects.




Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects

Monday, March 10, 2025

Diabetes News: Just 2 minutes of walking after eating..

Just 2 minutes of walking after eating can help blood sugar, study says

A new study says that getting up and moving after you eat- even if it's only for two minutes- can help control blood sugar levels. If you can't do that, try standing. It helps, too.



 Increasing evidence highlights that accumulating sitting time in prolonged bouts is detrimental to cardiometabolic health.

 Frequent short interruptions of standing significantly attenuated postprandial glucose compared to prolonged sitting; however, light-intensity walking was found to represent a superior physical activity break. The feasibility and longitudinal implications of breaking sedentary behavior with light-intensity walking should be investigated in a free-living setting.















News: Just 2 minutes of walking after eating... (CNN News) - Behind the headlines - NLM

Saturday, March 8, 2025

Doximity-Red Light Therapy Gets the Green Light, Sort of


The Wall Street Journal reports redlight therapy may have some benefit for the treatment of skin
cancer following radiation therapy.  The treatment, a type of light therapy called photobiomodulation that involves exposing the body to low levels of red or near-infrared light, purports to help users lose weight, look younger and balance mood. It’s popping up everywhere from hotel spas to European beehives.

While research shows some promise in certain areas like dermatology, it’s too soon to say it clearly provides health benefits more broadly—despite the many products being sold that seem to suggest otherwise.

Caution and Reservation should abound.

To sell photobiomodulation now is to put the commercial cart in front of the evidence,” says Jonathan Jarry, a science communicator at McGill University’s Office for Science and Society.

Dr. Praveen Arany, an associate professor of oral biology who led the research and founded a biotechnology company to develop light-therapy devices, believes there is evidence to suggest the treatment can improve immune response. 

In a clinic at Massachusetts General Hospital, patients with mood and cognitive disorders are also testing the treatment. Varying doses to the forehead have helped patients with depression find relief from the common side effects of antidepressants, says Dr. Paolo Cassano, an associate professor of psychiatry at Harvard Medical School and director of the photobiomodulation clinic. 

Red light is thought to work by penetrating the skin’s surface and boosting brain cells’ energy, oxygen, and blood flow to help them fire faster, he says. 

These opinions are not scientifically proven, and largely based on anecdotal reports.

Dr. Praveen Arany, an associate professor of oral biology who led the research and founded a biotechnology company to develop light-therapy devices, believes there is evidence to suggest the treatment can improve immune response. 

In a clinic at Massachusetts General Hospital, patients with mood and cognitive disorders are also testing the treatment. Varying doses to the forehead have helped patients with depression find relief from the common side effects of antidepressants, says Dr. Paolo Cassano, an associate professor of psychiatry at Harvard Medical School and director of the photobiomodulation clinic. 

Red light is thought to work by penetrating the skin’s surface and boosting brain cells’ energy, oxygen, and blood flow to help them fire faster, he says. 

In Oslo, Christophe Brod, chief executive of beekeeping technology company Beefutures, who was inspired by some of Jeffery’s work, asked him to collaborate on research investigating whether red light could help bees be healthier and more productive in the face of growing stressors, from pesticides to climate change. 

The red-light bees lived longer and recovered better from pesticide exposure and extreme weather. They also produced honey of a darker color, suggesting they may have flown further to different crops, says Brod, who is now developing a commercial red-light product that can be inserted into hives.

Tom O’Brien, who sustained a traumatic brain injury after a crane collapsed onto a parked car he was sitting in in 2016, started infrared and near-infrared light therapy with Cassano at Massachusetts General Hospital last year. O’Brien says that while other treatments didn’t seem to help, he started feeling happier and more energetic, and the pressure in his head eased, after trying photobiomodulation. 

“The LED light therapy lit a fire of recovery in my brain and my body,” he says. “The spark that was me has returned.”

Psychiatrists recognize that most depressive episodes are self-limited and this could explain the results in one patient.

The evidence for red light therapy as beneficial is very weak if not absent.

It however will be a money-maker for entrepeneurs.

Snake oil salesmen are still active.

Red-light therapy is generally considered safe. Some photobiomodulation devices have been cleared by the Food and Drug Administration.



Doximity

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