Wednesday, December 24, 2025

Nonhormonal Therapies Transform Hot Flash Treatment in Menopause | HCPLive

In 2025, major shifts to the landscape of non-hormonal therapies available for treating vasomotor symptoms (VMS) in postmenopausal women were reported, the most recent being the FDA approval of elinzanetant (Lynkuet) in this population on October 24, 2025.1




Elinzanetant, a neurokinin receptor antagonist, represents a method of treatment which, according to JoAnn V. Pinkerton, MD, division director of midlife health at UVA Health, has begun to reshape the VMS landscape.2 Thermoregulatory instability during menopause has been linked to overactivity in certain hypothalamic neurons caused by declining estrogen levels.

Risks associated with hormonal therapies have previously been reported to patients through boxed warnings on the products’ labeling.4 In the Women’s Health Initiative (WHI) trials, increased risks of stroke and breast cancer were reported in patients receiving menopausal hormonal therapy (MHT).

This revelation led to class-wide boxed warnings being added to MHT starting in 2003. However, the FDA noted that WHI participants had an increased age relative to the general population receiving therapy for hot flash relief, increasing their baseline risks.4

Compared to the mean age of 51 years in patients starting MHT, dementia findings in the WHI were based on women aged 65 to 79 years. The primary version of hormone therapy has also changed since this data was published, from oral conjugated equine estrogens plus medroxyprogesterone acetate to versions with transdermal estradiol, which reduces venous thrombosis risk.4Based on this information, the FDA announced actions to revise safety labelling for MHT on November 10, 2025. These changes included:4

  • Removing warnings about cardiovascular disease, breast cancer, and dementia
  • Removing most references to endometrial cancer
  • Removing recommendations to use the lowest dose for the shortest duration

Currently, warnings about breast cancer risk remain for labeling outside of boxed warnings for systemic therapy. Further research is needed to understand the link between MHT and breast cancer.4

“It's important to note that we need more data to make up for the dearth of research in this domain and until we better understand the full impact of MHT on breast cancer risk, women with a personal history of breast cancer remain ineligible for MHT,” said Nora Lansen, MD, chief medical officer at Elektra Health.4

Clinical Evidence Supporting Fezolinetant

During the period of boxed warnings for hormonal options, multiple nonhormonal treatments rose in the vasomotor symptom landscape. At the 2023 ACOG Annual Clinical & Scientific Meeting, Genevieve Neal-Perry, MD, PhD, professor at the University of North Carolina at Chapel Hill, presented data regarding the safety and efficacy of fezolinetant.3



Full disclosure below


Nonhormonal Therapies Transform Hot Flash Treatment in Menopause | HCPLive

Monday, December 22, 2025

(1) THE DIGITAL AGE DILEMMA | Blue Light interrupts Circadian Sleep Cycle




(1) THE DIGITAL AGE DILEMMA | LinkedIn

In today’s hyper-connected world, screens are unavoidable. From office desktops and smartphones to tablets and TVs, we are constantly absorbing information through digital devices. But this comes at a price—digital eye strain, also known as computer vision syndrome, is a growing health concern affecting professionals worldwide. One of the biggest culprits is the Blue light.

WHAT IS BLUE LIGHT? AND WHY DOES IT MATTER?
Blue light is a high-energy visible (HEV) light emitted by screens and artificial lightingBlue light is a high-energy visible (HEV) light emitted by screens and artificial lighting. While natural blue light from the sun regulates our circadian rhythm (sleep-wake cycle), prolonged exposure to artificial blue light—especially at night— can disrupt our sleep, cause eye fatigue, and even cause changes in vision over time.


HOW BLUE LIGHT AFFECTS YOUR HEALTH ?
Eye Strain & Fatigue: Extended screen time forces our eyes to work harder, leading to dryness, irritation, and blurred vision. light exposure can trigger migraines and tension headaches, especially in individuals prone to light sensitivity.

Disrupted Sleep Patterns: Screens before bedtime suppress melatonin production, making it harder to fall asleep and affecting overall sleep quality.Potential Long-Term Damage: Studies suggest that too much blue light can strain your eyes and may slowly harm your vision over time, especially as you get older.

WHY WORKING PROFESSIONALS ARE AT HIGHER RISK ?
If you spend hours in front of a screen for work, you’re especially vulnerable to blue light exposure and its consequences. Reports indicate that an average office worker spends 6-9 hours a day staring at a screen. Combined with poor ergonomics, artificial lighting, and minimal breaks, this creates a perfect storm for digital eye strain.

Some common warning signs include:
Frequent dry or irritated eyes
Increased sensitivity to light
Difficulty focusing, especially in the evening
Continuous focus at a close distance can weaken the eye’s ability to shift focus to far objects, causing temporary or long-term blurred distance vision.
Trouble falling or staying asleep

HOW TO PROTECT YOUR EYES WITHOUT QUITTING SCREENS
Since ditching screens isn’t an option for most professionals, here are practical, science-backed solutions to reduce eye strain and blue light exposure:

Follow the 20-20-20 Rule Every 20 minutes, look at something 20 feet away for 20 seconds to relax your eye muscles.

Adjust Screen Settings Use “Night Mode” or “Blue Light Filter” on your devices to reduce HEV light exposure, especially in the evening.

Wear Blue Light Blocking Glasses Invest in blue light filtering glasses, which reduce the amount of HEV light reaching your retina.

Blink More & Stay Hydrated Blinking keeps your eyes moist. When focusing on a screen, we blink 50% less than normal, leading to dryness.

Optimize Your Workspace Position your screen an arm’s length away and slightly below eye level to minimize strain. Use anti-glare screens or a matte screen protector.

Limit Screen Use Before Bed Avoid screens 1-2 hours before sleep or use apps like f.lux or Night Shift to reduce blue light emission.

DIGITAL WELLNESS IS KEY
Technology is essential, but our health should be a priority. By making small adjustments, you can significantly reduce digital eye strain and protect your vision, productivity, and well-being in the long run


Saturday, December 20, 2025

The Ghosts of Christmas Past, Present, and Future

Visit 3 Ghosts right there in the exam room.



👻 THE GHOST OF PATIENT PAST We time-travel back to 7th grade. I ask them to visualize themselves at that age—when the world was their oyster. The kid who wanted to be an astronaut, an athlete, or an artist. I ask: "If that 12-year-old walked in here and saw you today—on 12 medications, immobile, and hurting—what would they say?" This isn't about shame; it's about Cognitive Dissonance. It reconnects them with their original spark and highlights the drift between who they wanted to be and who they became.

👻 THE GHOST OF PATIENT PRESENT This is the reality audit. Most patients view themselves as passive passengers in a broken vehicle. I flip the script. We look at the metabolic bankruptcy happening right now. It demands they take a hostile takeover of their own biology.

👻 THE GHOST OF PATIENT FUTURE This is the binary choice. I force a visualization of two distinct timelines 10 years from now.

Timeline A: You stay on this road. You are wheelchair-bound, dependent on nursing care, or gone.

Timeline B: You pivot today. You are mobile, vibrant, and playing with your grandkids. It is a stark, visceral fork in the road.

THE VERDICT: WAKING UP THE CEO Why do I do this? Because these three ghosts serve one purpose: To wake up the CEO of your own health.

You cannot outsource your biology to a doctor, an insurance company, or a spouse. You are the Chief Executive of your body. The Ghost of the Past provides your history; the Ghost of the Present provides your balance sheet; and the Ghost of the Future provides your forecast.

But only the CEO can make the executive decision to change direction.

I want to hear from you: As a patient, would this "Scrooge" approach motivate you to change, or would you find it too intense? And to my fellow providers—how do you break through the wall of denial when data fails?


Better Than DoorDash or UberEats

 


Why Are Physicians Starting Businesses




Trends in physician entrepreneurshp:


1. New business models
2. Participation in non-clinical roles
3. AI edupreneurship
4. Women's health and femtech
5. Medical education, training, and development reform
6. The return of private practice
7. Direct payment care instead of only direct primary care
8. New generational attitudes about medicine as a job
9. Demographic change
10. The evolving medical cybernervous system
11. Patient entrepreneurship
12. Careers in entrepreneurial finance and investing


https://www.linkedin.com/posts/ameyers_trends-in-physician-entrepreneurshp-1-new-activity-7408098709697224705-d86G?utm_source=social_share_send&utm_medium=member_desktop_web&rcm=ACoAAAAqTbwBl7WHwBdULQ1iB1ThcCkr32EMVjE

Wednesday, December 17, 2025

Beating Lyme Disease with Hyperthermia Treatment: Sophia’s Story

Have you heard about Hyperthermia treatment for Lyme disease? This new treatment protocol is helping patients go from rock-bottom to recovery.

For many Lyme sufferers, living with the disease is part of everyday life. Between 10-20% of people diagnosed with Lyme disease report lingering symptoms despite treatment. For a long time, Sophia Denison was no different. She had been suffering from Lyme since she was a young girl.

Sophia’s strength is undeniable, but a lifetime of aches and pains prompted her to seek alternative medical advice and new treatment modalities. Sophia was open to anything, though not much seemed to be helping.

She kept searching, and one day, she heard from a neighbor about a treatment being done at a clinic in Germany. The treatment, called hyperthermia, promised hope where other methods had failed. And finally, it was this breakthrough therapy that changed Sophia’s life for the better.

As she shared in a recent episode of Whole Body Health with FLCCC Senior Fellow, Dr. Saleeby, “I got diagnosed and got proper treatment after many trials and tribulations. And I am 100% symptom-free now. I’m in remission.”

Could this be the treatment that Lyme sufferers have been hoping for? Hyperthermia may sound new, but it has actually been around for a long while, used in various forms of medicine. Sophia’s triumph can teach us so much about this promising treatment for Lyme disease. So, let’s learn more!

Sophia’s Journey to Treat Lyme Disease

Sophia Denison, a college student at the Savannah College of Art and Design in Georgia, has been battling Lyme disease since she was seven years old. For over a decade, she struggled with a myriad of debilitating symptoms, including severe abdominal pain and even psychiatric manifestations.

Despite numerous doctor visits and countless medications, Sophia remained undiagnosed and untreated until she was 19. “I was perpetually anxious; like, my stomach would just drop over and over and over again,” she shared while describing her experience to Dr. Saleeby.

If you know anyone with Lyme, the entire episode is a must-watch. Sophia describes her symptoms in great detail, and Dr. Saleeby weighs-in as an integrative medicine doctor with years of experience treating Lyme patients.

Watch the entire video below!

The Challenge of Treating Lyme

Treating Lyme disease is notoriously challenging. The CDC estimates up to 476,000 Americans are diagnosed and treated for the tick borne disease every year. Many Lyme patients face misdiagnosis and ineffective treatments, leaving them in a state of chronic illness. The bacteria responsible for Lyme, Borrelia burgdorferi, can evade the body’s immune system and form protective biofilms, making it resistant to conventional antibiotic therapy, especially if patients are undiagnosed and untreated for too long.

Patients with Lyme disease often experience a range of symptoms, including mood alterations, that can complicate treatment further. As Dr. Saleeby explains, “Almost 50% of people with Lyme disease have some mood-altering psychiatric manifestations that to a trained psychiatrist, they would think that’s totally functional.” Of course, when you experience a range of symptoms with no clear diagnosis, it’s only natural to feel like you’re going mad. The uncertainty and lack of effective treatment can lead to significant psychological distress, compounding the physical symptoms and making the journey to recovery even more daunting.

tick that causes Lyme disease

The symptoms of Lyme disease often overlap with conditions such as Chronic Fatigue Syndrome (CFS) and fibromyalgia. Patients may experience persistent fatigue, widespread pain, and cognitive difficulties, which are also common in CFS and fibromyalgia. This overlap can lead to further confusion and misdiagnosis. The complexity and variability of symptoms make it challenging for both patients and doctors to pinpoint the exact cause of their suffering.

Hyperthermia brings the promise of a treatment program capable of completely neutralizing this chronic infection. So, let’s learn how it works!

About Hyperthermia Treatment

The use of fever to combat infections dates back to ancient civilizations. For example, ancient Greeks and Egyptians used heat therapy to treat various illnesses. Hippocrates, often seen as the “Father of Medicine,” advocated for the induction of fever to treat certain diseases. He believed that fever was a natural defense mechanism of the body to combat illness.

Jumping ahead to the early 20th century, you’ll find a great example of hyperthermia therapy. Julius Wagner-Jauregg, an Austrian physician, won the Nobel Prize in Medicine in 1927 for his work on malaria fever therapy. He discovered that inducing fever through malaria infection could help treat syphilis patients. The high fever caused by malaria was effective in killing the bacteria responsible for syphilis before the advent of antibiotics.

whole body hyperthermia treatment

Hyperthermia treatment partly works due to heat shock proteins (HSPs). When body temperature rises, the HSPs produced are said to:

  1. Repair Proteins: Refold and fix damaged proteins.
  2. Protect Cells: Prevent cell death and stabilize structures.
  3. Boost Immunity: Enhance immune response by promoting antigen presentation.
  4. Reduce Inflammation: Modulate and decrease excessive inflammation.

Hyperthermia is also used for other illnesses besides Lyme disease, including cancer treatment, where it helps to weaken tumor cancer cells, making them more susceptible to radiation and chemotherapy. This method, known as oncologic hyperthermia, involves heating the body or parts of the body to high temperatures to enhance the immune response and improve treatment outcomes.

The higher temperatures are also said to assist in detoxification, improving blood flow and clearing stubborn pathogens out of the body. This also may have the effect of improving immunological function and empowering the cells that fight infection.

How Hyperthermia Works for Lyme

Hyperthermia has immense potential in the treatment of Lyme disease.

Whole-body hyperthermia works by heating the body to temperatures as high as 107 degrees Fahrenheit, effectively mimicking a high fever. This process breaks down the biofilms protecting the Lyme bacteria, allowing antibiotics to eliminate the bacteria more effectively. As Sophia describes, “They heat your body up to 107.24 degrees for a few hours and intravenously give you antibiotics to kill the spirochetes.”

Sophia traveled to Clinic St. George in Germany to undergo this treatment. The process included comprehensive detox therapies, such as blood ozone therapy and colonic cleanses, to mitigate herxing (a reaction to the release of toxins from dying bacteria). “For the first time in my life, I didn’t feel full body pain. And my brain immediately felt like I could think,” she recalls.

Hyperthermia, in combination with a whole-body approach, is leading to a complete reversal of symptoms. Could this be the long sought-after cure? Rest assured, Dr. Saleeby and FLCCC’s clinical team will continue to monitor this incredible treatment protocol.

FLCCC Treatment Protocols

Looking Ahead for Lyme

The success of hyperthermia treatment for Lyme disease, as experienced by Sophia Denison, offers hope to many suffering from this debilitating illness. While traditional treatments have their place, exploring alternative therapies like hyperthermia can provide a much-needed solution for those who have not found relief. As Dr. Saleeby continues to advocate for integrative approaches through his platform, Whole Body Health, patients can look forward to more innovative treatments on the horizon.

Sophia’s journey from chronic illness to remission is a testament to the resilience and determination of Lyme patients. Her story is inspiration for others battling Lyme disease, proving that perseverance and exploring new treatment options can lead to astonishing recoveries.

This has officially crossed from frustrating into absurd. This is a photo of the instruction booklet we had to assemble for our team.

This has officially crossed from frustrating into absurd. This is a photo of the instruction booklet we had to assemble for our team. We emp...