Monday, December 8, 2025

A SINGLE AMINO ACID CAN TREAT CHILDHOOD PSYCHOSIS-PRECISION MEDICINE

Scientists just turned down severe psychosis in children with a single amino acid that costs less than coffee. No gene editing. No heavy drugs. Just targeted biochemistry.



Data from 121 patients worldwide shows that, for some, severe mental illness is truly monogenic.

Think about that.

For decades, psychiatry insisted: hundreds of genes plus environment equals mental illness. Then researchers found GRIN2A null variants—broken copies of one gene—can directly cause schizophrenia, mood disorders, anxiety in children as young as 8.

In some cases, no seizures. No intellectual disability. Just isolated mental illness starting in childhood.

Traditional Psychiatry Reality:
↳ Trial-and-error medications for decades
↳ "Mysterious" early-onset psychosis
↳ Children labeled as permanently broken

The GRIN2A Discovery:
↳ Single gene = direct cause identified
↳ L-serine showing documented improvements
↳ Childhood onset explained molecularly


But here's what let's children be relieved:

Four patients with GRIN2A-null psychiatric disorders received L-serine—an amino acid that boosts NMDA receptor activity. All four showed documented clinical improvements. Reduced hallucinations. Less paranoia. Children emerging from psychosis using a supplement from any health store.

What changes everything:
↳ Genetic testing crucial for early-onset cases
↳ Targeted interventions complementing traditional drugs
↳ "Untreatable" becomes "specific circuit defect"
↳ Families get molecular answers, not stigma

The Multiplication Effect:

1 genetic test = precision diagnosis
10 identified variants = targeted protocols
100 research centers = new monogenic causes discovered
At scale = psychiatry becomes molecular medicine

24 million have schizophrenia worldwide. If GRIN2A explains 1%, that's 240,000 people who might benefit from targeted NMDA strategies—moving beyond one-size-fits-all drugs.

Children developing psychosis at 10 instead of 25—now we know why. Families watching deterioration—now they have a lever.

We spent a century treating mental illness as mysterious suffering.
Now it's becoming readable code.

Because when four children improve on L-serine—after conventional treatments had not resolved their symptoms—you realise:

The revolution isn't understanding that genes cause mental illness.

It's modulating the specific broken circuit instead of relying only on broad sedation.


https://www.linkedin.com/posts/drmarthaboeckenfeld_scientists-just-turned-down-severe-psychosis-activity-7403684014081060865-bMlO?utm_source=social_share_send&utm_medium=member_desktop_web&rcm=ACoAAAAqTbwBl7WHwBdULQ1iB1ThcCkr32EMVjE

The Home Health Cuts That No One Wants To Talk Abou



CMS REMAINS SCHIZOPHRENIC
 
On one hand Medicare pushes remaining at home in lieu of going to a SNF.  Elderly patients do better at home surrounded by loved ones.  Many patients do not have long term insurance coverage, which shifts them to state run programs under Medicaid.  Caregivers are amongs the worst paid in health care.

Many patients require post op or acute care at home if a caregiver is present.  Outcomes are very dependent upon proper care.

Medicare home health was just hit again. CMS backed off the brutal 6.4 percent payment cut it originally proposed and finalized a 1.3 percent cut instead. Providers are calling it relief, but temporary relief doesn’t solve a structural problem that has been building for years. The methodology used to calculate these rates is still broken. Costs are rising. Staff shortages are worsening. Agencies are closing. And beneficiaries are the ones who will feel it first.

Behind the scenes, cumulative cuts since 2020 now approach fourteen percent. CMS’s formula under PDGM has been flawed since implementation, relying on assumptions about agency behavior that simply never reflected real operations. Meanwhile, MedPAC continues to argue that agencies are overpaid based on its own margin analysis even as nonprofit agencies report the weakest financials they have ever seen. The entire system is drifting toward a collapse that policymakers refuse to acknowledge.

What makes this situation worse is that most Americans do not understand how limited Medicare home health coverage has always been. It does not provide the type of long term personal care or custodial care families expect. Medicare home health is medically necessary and intermittent. It requires a physician plan of care, the patient must be homebound, and services are tied to skilled needs such as nursing, therapy, or wound care. You cannot simply “get help at home” under Medicare. You cannot get daily long term care, bathing, meal preparation, or ongoing supervision. Even when a patient qualifies, the benefit is short lived and heavily restricted.

Cuts like these shrink provider capacity even further. When agencies lose staff because reimbursement doesn’t support wages, the first thing that disappears is visit availability. Homebound beneficiaries face longer wait times. Rural communities lose access entirely. Hospitals discharge patients sooner and sicker, expecting home health to pick up the work while funding is moving in the opposite direction. The disconnect keeps widening.

Absent action from Congress, CMS will continue applying temporary and permanent rate adjustments every year. Agencies will continue trimming services, laying off headquarters staff, and shifting resources away from complex patients. A benefit that was already narrow will become even narrower. For seniors and caregivers this means fewer visits, fewer agencies willing to accept new patients, and a higher chance of being redirected to a skilled nursing facility instead of staying at home.

There are also downstream consequences that are never mentioned. CMS actuaries have already warned that reducing home health capacity pushes more beneficiaries into skilled nursing facilities, increasing Part A spending over ten years. Meanwhile hospital systems are trying to expand at home programs because they reduce readmissions, but they cannot scale if the home health workforce keeps shrinking. The math no longer works.

New fraud crackdowns add another layer of distortion to the payment formula. Several multi million dollar home health fraud cases from 2024 and 2025 involved sham providers using stolen identities to bill Medicare. These cases inflate cost report data and influence rate setting. CMS acknowledged these anomalies but says it lacks authority to filter them out. Providers are left paying for the behavior of criminals rather than being rewarded for doing things correctly.

Medicare home health has never been designed to cover true home care. Now even the limited version is in jeopardy. Families cannot rely on Medicare alone. Agents need to be having the conversation now before someone learns the hard way that Medicare does not pay for what they assumed it would. There are two realistic private market solutions.

The first is standalone home health care insurance that provides cash benefits to help pay for skilled or custodial support in the home. The second is a Hospital Indemnity plan that includes a home care rider. These products fill the gap created by Medicare’s limited home health benefit and the widening gap caused by CMS’s annual cuts. They are inexpensive compared to traditional long term care insurance and they pay when Medicare will not.

As Medicare continues to tighten payments and agencies are forced to cut back, the burden shifts to families. If a client wants to stay home and avoid facility placement, they need additional coverage. The warning signs are here. The trend is undeniable. Agents who educate their clients today prevent financial and emotional chaos tomorrow.

These short term fixes emphasize the importance of a NATIONAL HEALTH TRUST for American health.

Friday, December 5, 2025

(Castlemen'' Disease)

Castleman disease is a group of rare disorders that involves lymph nodes that get bigger, called enlarged lymph nodes, and a wide range of symptoms. The most common form of the disorder involves a single enlarged lymph node. This lymph node is usually in the chest or neck, but it can occur in other areas of the body as well. This form of the disorder is called unicentric Castleman disease (UCD).

Multicentric Castleman disease (MCD) involves multiple regions of enlarged lymph nodes, inflammatory symptoms and problems with organ function. There are three types of MCD:

  • HHV-8-associated MCD. This type is linked to human herpes virus type 8, called HHV-8, and human immunodeficiency virus (HIV).
  • Idiopathic MCD. The cause of this type is unknown. This also is called HHV-8-negative MCD.

    The most serious form of this type of MCD is known as iMCD-TAFRO. This condition gets its name from the symptoms it causes.

  • POEMS-associated MCD. This type is linked to another condition called POEMS syndrome. POEMS syndrome is a rare blood disorder that damages nerves and affects other parts of the body.

                    Enlarged lymph follicle in Castlemen's Disease


Idiopathic Multicentric Castleman Disease (iMCD): The first-line treatment is typically an anti-interleukin-6 (IL-6) monoclonal antibody.


Siltuximab (brand name Sylvant) is the only FDA-approved medication for iMCD and is the preferred initial therapy.
Tocilizumab (brand name Actemra), another anti-IL-6 agent, is also used, particularly in Japan or if siltuximab is unavailable.
Corticosteroids may be used in severe cases, often in combination with other therapies, to control inflammation quickly.
For patients who do not respond to anti-IL-6 therapy, second-line options include other immunomodulators (e.g., sirolimus, bortezomib) or chemotherapy regimens.


HHV-8-associated Multicentric Castleman Disease: This form is strongly linked to the human herpesvirus 8 (HHV-8) and often occurs in patients with HIV.
Rituximab (brand name Rituxan), a B-cell-targeting antibody, is generally the highly effective first-line treatment.
Antiviral drugs to block the activity of HHV-8 or HIV (such as antiretroviral therapy for HIV-positive patients) are often included.
Chemotherapy may be combined with rituximab for severe, life-threatening cases.
POEMS-associated Multicentric Castleman Disease: Treatment is directed at the underlying plasma cell disorder that drives the syndrome. This may involve radiation therapy for localized disease or chemotherapy-based regimens for more widespread disease. 
Due to the complexity and rarity of the disease, it is highly recommended to consult a physician or a center with expertise in Castleman disease. 

The Castleman Disease Collaborative Network (CDCN) offers resources and information on expert centers. The Castleman Disease Collaborative Network plays a crucial role in advancing research and treatment for Castleman disease. Through innovative studies, patient support initiatives, and a commitment to collaboration, the CDCN is making strides in improving outcomes for those affected by this rare condition. For more information, you can visit their official website at CDCN. 

Castleman Disease Collaborative Network | CDCN











 


 

Thursday, December 4, 2025

Survival

We talk a lot about fixing healthcare, but none of it matters if the people delivering care cannot survive the system themselves.

More than half of physicians in America report burnout.


The same is true for nurses. These are not small numbers.

These are the people holding the entire system together, and they are exhausted.

When physicians tell surveyors they are thinking of leaving the workforce, we should be listening.

When nurses say they cannot sustain the pace, we should be listening.

And when clinicians at every level say the loss of autonomy is breaking them, we must listen.

Burnout is not a personal failure. It is a signal that the system has pushed its workforce past the breaking point.

When the work becomes more about documentation than healing, when decisions are dictated by insurance algorithms instead of clinical judgment, when autonomy disappears, purpose disappears.

That is when people walk away.

If we want a healthcare system that works, we need to protect the people doing the work.

That starts with restoring autonomy, rebuilding meaningful patient connections, and giving clinicians space to practice the medicine they were trained to deliver.

Healthcare will not heal until the healers do.


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Heart Attacks, What else is going on?

What causes heart attacks besides, placque and cholesterol? 



How do you explain the guy in his early 30s or 40s who exercises daily, eats clean, has normal labs, coronary calcium score of zero, yet drops from a heart attack?
No warning. No plaque buildup. Perfect LDL. Someone considered very low risk
The LDL model of heart disease is broken
It can’t explain why:
- half of heart attacks happen with normal LDL
- many with high LDL never have heart issues
- veins never clog unless turned into arteries
- you can have a massive heart attack with clean arteries
Instead of questioning the model, cardiology just keeps lowering the “optimal” number
LDL IS NOT THE INITIATOR. Something upstream must break first.
👉 The Missing Physics

Arteries aren’t designed to be scraped by blood
They’re lined with hydrophilic tissue that forms structured water (exclusion zone water aka EZ water) which is a gel-like negative layer that excludes blood components like:
- RBCs
- platelets
- bacteria
- LDL

If EZ is intact: blood never touches the arterial wall --> so no injury --> no inflammation --> no plaque
This is never even mentioned in the flawed “cholesterol clogs” narrative

So what is plaque?
Histology shows ~87% clot + repair material

Sequence: Damage --> clot --> repair --> plaque
(NOT: LDL --> plaque --> damage)
Plaque forms where flow becomes abnormal (high mechanical stress)
And heres the paradox:
People with severe plaque often feel fine bc the body builds collaterals (natural bypasses) to restore flow

Meanwhile, many heart attacks happen with no major blockage at all
They arent blocked pipe scenarios..they are:
- clotting failures
- autonomic stress failures
- flow collapse under oxidative stress

NOT “you ate too much butter and red meat”
So what destroys this EZ Water?
- circadian disruption
- chronic stress
- glucose heavy metabolism year round
- high O6 / AGEs
- poor mitochondrial function
- nnEMFs (alone reduce EZ up to 20%), low sunlight, no grounding
- pollution, metals, BPA
- oral infections

These steal electrons --> collapse EZ --> expose artery --> raise clot risk
What protects the artery?
Everything that supports EZ water + mitochondrial redox:

- sunlight (IR especially)
- cold
- sauna
- grounding
- mineral-rich water
- animal fats & metabolic flexibility
- strong HRV/parasympathetic tone
- darkness at night so melatonin can repair endothelium

When EZ is strong = endothelium protected
= smooth flow =RBCs repel (no clumping) = clots hard to trigger

That’s the real prevention strategy

So again heart disease is not:
- an LDL issue
- a saturated fat issue
- a cholesterol issue

It’s blood physics + redox issue

The danger starts when EZ collapses

So instead of obsessing over LDL, protect the environment your heart pumps through
Modern cardiology only saves you once you’re dying
If you want to avoid the table, stop breaking EZ water and start building it
Sunlight. Movement. Grounding. Dark nights. Low oxidative stress.

That’s how you protect the most energy hungry organ in the body

A SINGLE AMINO ACID CAN TREAT CHILDHOOD PSYCHOSIS-PRECISION MEDICINE

Scientists just turned down severe psychosis in children with a single amino acid that costs less than coffee. No gene editing. No heavy dru...